MRI findings uncover an unexpected mismatch between Alzheimer’s pathology and cognitive function in a unique case study.

A US woman with Down syndrome exhibited no symptoms of Alzheimer’s disease despite her brain showing advanced pathology.

The brain of an American woman with Down syndrome showed all the classic signs of Alzheimer’s disease, yet she remained ...

Decades of tests had shown that she had both Down syndrome and an intermediate level of Alzheimer's. Physical examinations ...

Just one week ago, 17-year-old Joe Slachciak was diagnosed with leukemia. The Grand Island teen is now using his battle to ...

For 10 years, a woman with Down syndrome defied what many scientists believed to be an inevitability. Despite carrying the ...

Studies reveal that people with Down syndrome (DS) have over a 90% lifetime risk of developing dementia caused by Alzheimer's ...

A proof-of-concept study shows that CRISPR-Cas9 can eliminate extra chromosome copies in Down syndrome cells. The method restores normal gene function but is not yet ready for human trials. Scientists ...

Both Tabrizi and Yang think that knocking down MSH3 could stave off HD pathology. Tabrizi noted that MSH3 also modifies other run-on repeats, including those causing fragile X syndrome, myotonic ...

Down syndrome is caused by the presence of a third copy of the 21st chromosome. The condition occurs in approximately 1 in 700 live births and is relatively easy to diagnose at early stages of ...

Gene editing techniques may eventually allow trisomy to be treated at the cellular level, according to an in vitro proof-of-concept study. Down syndrome is caused by the presence of a third copy ...