Microsoft has unveiled a new deep-learning model called Biomolecular Emulator-1 (BioEmu-1). This model can “generate thousands of protein structures” hourly. The company has also released the model as ...

Doctors can use your C-reactive protein (CRP) levels to help diagnose rheumatoid arthritis and see how well your treatment plan is working. Levels typically rise if you have inflammation or ...

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China ...

In a study published in Nature Structural and Molecular Biology, scientists from the Department of Medical Biochemistry and Biophysics at Karolinska Institutet, have discovered that water ...

The flexibility in their structure allows peptides to interact effectively with different receptors in the body, making them essential in signaling pathways. On the other hand, proteins are larger ...

When the team analyzed the transthyretin on the grid, they found that the protein forms asymmetric structures with two differently shaped binding pockets. Based on the more than 200 crystal ...

These compounds have activities as receptor-interacting protein kinase 1 (RIPK1) inhibitors and may potentially provide treatment and/or prophylaxis of inflammatory and neurodegenerative diseases ...

Members of the lipid-activated protein kinase C isoenzyme family (PKCs ... partner that controls PKC activity via sequestration of the C-terminal tail of the kinase. The high-resolution structure of ...

This review offers a comprehensive overview of the functional structures of picornaviruses’ 2C protein. We summarize the mechanisms by which the 2C protein enhances viral replication. 2C protein ...

Botulinum neurotoxin serotype A is synthesized in Clostridium botulinum as a ~150,000 M r single chain protein (1,296 ... We describe here the crystal structure of BoNT/A and then use this ...