crypt abscesses (accumulation of inflammatory cells within the crypts of the intestine), depletion of the mucin layer in the intestine, surface integrity, chronic inflammatory cell infiltration ...

and crypt damage, demonstrating strong anti-inflammatory and mucosal barrier-protective effects. In TNF ΔARE ileitis models, TP-317 lowered intestinal permeability and reduced pro-inflammatory ...

One example is Wnt signaling, which plays a key role in maintaining stem cell homeostasis within the intestinal crypt. Enteric glial cells have been shown to contribute to this regulation (3). However ...

The gut is a tubular organ responsible for nutrient absorption and harbors our intestinal microbiome. This organ is composed of a multitude of specialized cell types arranged in complex ...

70 These data suggest that Paneth cell factors may not be required to prevent colonisation of the small intestinal crypt by commensal flora, or that the remaining 5% of the Paneth cells and other ...

Crypt damage was scored from 0 to 4 ... that COP could reinforce the intercellular connections and had a significant protective effect on intestinal mucosa, which is another mechanism by which COP ...

Goblet cells in the vicinity of metaplastic patches also expressed both gastric and intestinal antigens. MUC5AC/MUC2 containing goblet cells were most common near the villus tip but were also seen at ...

The Asia Pacific organoids and spheroids market is experiencing unprecedented growth, with market valuation projected to surge from USD 246.66 million in 2024 to an impressive USD 1,444.49 million by ...