Once a mapping population is available, the present method allows a single investigator to identify a causative mutation in only 8 working days of hands-on time. Furthermore, de novo marker ...

Driver mutations are the pathophysiological hallmark of the disease, but the role of mutation clearance after transplantation is unclear. In patients with myelofibrosis, clearance of driver ...

Genome editing with CRISPR-Cas is often associated with the induction of mutations. However, a team of researchers from the Swiss University of Lausanne now shows that it can also be used to ...

For 30 years, researchers have known that Huntington's is caused by an inherited mutation in the Huntingtin (HTT) gene, but they didn't know how the mutation causes brain cell death. A study ...

Researchers in the group of Dr. Myriam Charpentier discovered a mutation in a gene in the legume Medicago truncatula that reprograms the signaling capacity of the plant so that it enhances ...

Radiation-induced mutation is unlikely to have induced genetic differences between dog populations in Chornobyl City and the nearby Chornobyl Nuclear Power Plant. Radiation-induced mutation is ...

This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer. While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms ...

A comprehensive analysis of over 500,000 human protein variants reveals that 60% of disease-causing missense mutations reduce protein stability In a recent study published in Nature, researchers ...

The new map, appearing today in the online edition of Nature, is the first to incorporate shorter-scale shuffling, (non crossover ... sexes can contribute to mutations passed to offspring.