Costimulatory molecules, the signals of which act in tandem with those from the T cell receptor (TCR) to activate cellular immunity, can help fuel antitumor activity. The promise of costimulatory ...

The therapies were targeted at costimulatory molecules, B and T cells, innate immune mechanisms and mesenchymal stem cells. Results from these studies bring new insights for real effective ...

these two proteins provide both the T cell receptor and costimulatory activation signals required to activate tumor-infiltrating CD4 and CD8 T cells in an antigen-independent manner. In essence ...

Transplantation of organs or tissues between genetically nonidentical individuals of the same species (and different species) is plagued by rejection and its associated problems. "Foreignness" is ...

Rondo Therapeutics, a privately held biopharmaceutical immuno-oncology company pioneering the development of next-generation T cell-engaging bispecific antibodies for the treatment of solid tumors, ...

Rondo Therapeutics Presents Preclinical Data at ASCO GU for its Novel CD28 x Nectin-4 Costimulatory Bispecific ... the development of next-generation T cell-engaging bispecific antibodies for ...