Costimulatory molecules, the signals of which act in tandem with those from the T cell receptor (TCR) to activate cellular immunity, can help fuel antitumor activity. The promise of costimulatory ...

Rondo Therapeutics, a privately held biopharmaceutical immuno-oncology company pioneering the development of next-generation ...

these two proteins provide both the T cell receptor and costimulatory activation signals required to activate tumor-infiltrating CD4 and CD8 T cells in an antigen-independent manner. In essence ...

The therapies were targeted at costimulatory molecules, B and T cells, innate immune mechanisms and mesenchymal stem cells. Results from these studies bring new insights for real effective ...