Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

This compromises normal hematopoiesis, leading to anemia and immune dysfunction. This is demonstrated by the susceptibility to opportunistic diseases (e.g., bacterial infections) in AML patients.

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

Clonal hematopoiesis becomes increasingly common with age. Here the authors track stem cell dynamics in monozygotic twins and provide evidence that clonal hematopoiesis in later life reflects weak ...

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston. (B.C.-C., N.A.V.G., N.L.P., L.P.E., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S ...

Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China Hefei National Research Center for ...

Myelosuppression, or bone marrow suppression, is defined as a decrease in the ability of the bone marrow to produce blood cells. This may result in a lack of red blood cells (anemia), white blood ...

and discovery of age-related clonal hematopoiesis. Ding has been recognized several times among Thomson-Reuters’ surveys of influential researchers, including listing among ‘The World’s Most ...

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© 2025 American Heart Association, Inc. Cardiovascular Research Center, New York University Langone Health, New York University Grossman School of Medicine. (A.A.C.N ...

Combination therapy with anti-angiogenic drugs and immune checkpoint inhibitors has shown enhanced clinical activity and has been approved for the treatment of multiple tumor types. Despite extensive ...