Monoallelic loss of PTEN and ARID1A is identified in normal colonic epithelium. The resulting haploinsufficient phenotypes ...

This compromises normal hematopoiesis, leading to anemia and immune dysfunction. This is demonstrated by the susceptibility to opportunistic diseases (e.g., bacterial infections) in AML patients.

Clonal hematopoiesis (CH) has been associated with a variety of adverse outcomes, most notably hematologic malignancy and ischemic cardiovascular disease. A series of recent studies also suggest that ...

Department of Cardiology, The University of Texas MD Anderson Cancer Center, Houston. (B.C.-C., N.A.V.G., N.L.P., L.P.E., V.S.K.S., A.M.O., J.L., G.M., O.H., A.D., S ...

Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China Hefei National Research Center for ...

1Department of Immunology, Center for Systems Immunology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania. 2School of Medicine, Tsinghua University, Beijing, China.