Mitogenic growth factors share a final common signalling pathway: the cell cycle (Fig. 2). Quiescent (G0) cells enter a gap period (G1), during which the factors necessary to DNA replication for ...
Background While p53 mutations occur early in Barrett’s oesophagus (BE) progression to oesophageal adenocarcinoma (EAC), their role in gastric cardia stem cells remains unclear. Objective This study ...
1Department of Obstetrics and Gynecology, Peking University Third Hospital, China 2Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China. 3Biobank, Peking ...
Circulating tumor cells (CTC) are the smallest functional units of cancer and precursors of fatal metastasis. We previously used an unbiased multilevel approach to discover a unique ...
This valuable study uses zebrafish as a model to reveal a role for the cell cycle protein kinase CDK2 as a negative regulator of type I interferon signaling. The evidence supporting the authors' ...
The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...
At the same time, analysis of cell cycle-specific genes revealed that in iDKO Sertoli cells can re-enter the cell cycle. In particular, genes involved in G0-S transition and G2-M transition were ...
cdktfVersion The version of CDKTF to use false 0.20.11 terraformVersion The version of Terraform to use false 1.10.5 workingDirectory The directory to use for the project false./ ...
Palbociclib has been shown to be effective in promoting p53 transcription after irradiation as well. There is no doubt that targeting cell cycle machinery, and especially cyclin-dependent kinase ...
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