Most drugs are metabolized by CYP3A enzymes, and variations in expression levels of these enzymes are believed to determine whether patients will have a positive or adverse drug response.

Drinking “large amounts” of alcohol while taking statins is also dangerous. The NHS adds: “If you're prescribed a statin, you ...

Potentiated by CYP3A inhibitors; reduce alprazolam dose; caution with cimetidine, nefazodone, fluvoxamine; caution with weaker CYP3A inhibitors (eg, fluoxetine, propoxyphene, oral contraceptives).

"Certain classes of drugs — most notably statins — are metabolized (broken down) in your intestines by an enzyme called CYP3A ...