In the mammary stroma of aged mice (25-32 months old), Cdkn2a expression is upregulated approximately ... are also elevated in the mammary glands of aged mice (122). Several key signaling pathways ...

Targeting mitochondrial retrograde signaling may therefore be promising in the treatment or prevention of metabolic disorders ...

In summary, enalapril significantly mitigated multiple pathological markers associated with aging, including lipid droplets, amyloid, glycogen deposition, and fibrosis, in the brain, kidneys, liver, ...

7 refine our understanding of the signaling effects of oncogenic KRAS. Rather than activating multiple effectors, mutant KRAS signals preferentially through the RAF–MEK–ERK pathway ...

The brain of humans and other animals is known to contribute to the protection of the body from infections. Past studies have ...

The hormone adrenomedullin disrupts insulin signaling in blood vessel cells, contributing to systemic insulin resistance in obesity-associated type 2 diabetes, according to a new study. Blocking ...

New research shows that a network of subcellular structures similar to those responsible for propagating molecular signals that make muscles contract are also responsible for transmitting signals in ...

Investigation of the association of CTRB2 exon 6 deletion with time to progression and overall survival in pancreatic ductal adenocarcinoma. This is an ASCO Meeting Abstract from the 2025 ASCO ...

Although gut microbiota and lipid metabolites have been suggested to be closely associated with type 2 diabetes mellitus (T2DM), the interactions between gut microbiota, ...

But still, early findings are a promising signal of quality improvement – a useful benefit of all the pieces of the Quality Pathway working together. If there continue to be significant ...