The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that’s prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...

Antifungal azoles are also widely used as a ... Instead, they found that azole-induced reduction of ergosterol increases the activity of cellular mitochondria, the "powerhouse" of the cell ...

In 1981, the first azole antifungal, the diazole ketoconazole, was introduced to the market; then, in the early 1990s the first-generation triazoles, fluconazole and itraconazole, became available.

The findings, reported in Nature Communications, also solve a decades-long scientific puzzle that's prevented drugmakers from successfully using azole antifungal drugs to treat visceral ...

Second, there is a greater chance of drug interactions. Azole antifungals (e.g., fluconazole, itraconazole and voriconazole) alter metabolism of cyclophosphamide, a cytotoxic agent, through ...

Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended. See Contraindications; other azole antifungals: not recommended. Potentiates CNS depression with alcohol, psychotropics ...

Fluconazole, a very safe and effective azole antifungal, requires a much higher dose in children (12 mg/kg/day) compared with adult patients. In addition, the neonatal field is exploring ...

Potent CYP3A4 inhibitors (eg, macrolides, protease inhibitors, reverse transcriptase inhibitors, azole antifungals): not recommended. Use caution with less potent CYP3A4 inhibitors (eg ...

Chromated arsenicals are a group of pesticides that protect wood against termites, fungi and other pests that can degrade or threaten the integrity of wood products, and the Environmental Protection ...

The achievement of the first sales milestone already in the second year of commercialization is a testament of the commercial capability of our partner AKP in this important market. The strong sales ...

While occurrence and risks of azole antifungals in wastewater and meat industry have been studied, their presence in surface water and potential threats to water quality are underexplored. This ...

For Cresemba, this comprises a milestone payment for sales in Canada, by AVIR Pharma Inc, as well as the first sales milestone payment for the Middle East and North Africa (MENA) region, by Hikma ...