Biotech Alert: Searches spiking for these stocks today
These names in the biotech sector are seeing a substantial increase in search activity today, as determined by InvestingChannel. They ...
Nature22d
Conformational changes: How small is big enough?
In chemotaxis, the aspartate receptor becomes an inhibitor of the kinase cascade. The aspartate receptor is also induced into becoming a better substrate for methyltransferase, thereby allowing ...
Nature11d
Apoptosis in animal models of virus-induced disease
Two cleavage events at aspartate (Asp) residues are required ... IFNα and IFNβ signalling involves the Janus kinase (JAK) family of cytoplasmic tyrosine kinases and the signal transducers ...
thecardiologyadvisor.com28d
December 2024 Recap: Drug Pipeline Updates
N-methyl-D-aspartate receptor antagonist, sigma-1 agonist, and aminoketone CYP2D6 inhibitor Treatment of Alzheimer disease agitation. Phase 3 trial results Tolebrutinib (Sanofi) Brain-penetant Bruton ...
BMJ24d
Tofacitinib for the treatment of ankylosing spondylitis: a phase III, randomised, double-blind, placebo-controlled study
Up to week 48, mean haemoglobin, lymphocytes, neutrophils, alanine aminotransferase, aspartate aminotransferase and cholesterol were stable over time; mean creatine kinase increased slightly over time ...
BMJ1d
Upadacitinib for psoriatic arthritis refractory to biologics: SELECT-PsA 2
Background Upadacitinib is a Janus kinase inhibitor under evaluation for the treatment ... Isolated grade 3 increases in alanine aminotransferase or aspartate aminotransferase were observed in ≤1% of ...
The EMBO Journal9d
Exploiting metabolic vulnerability in glioblastoma using a brain-penetrant drug with a safe profile
In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...
dermatologyadvisor8d
FDA Alert: Pulmonology Drug Approvals, Recalls, and Device Updates
FDA 2025 pulmonology drug alerts, including drug approvals/warnings, vaccine approvals, and medical device recalls/updates.
New England Journal of Medicine Publishes: Efficacy of Zenocutuzumab in NRG1 Fusion-Positive Cancer
UTRECHT, The Netherlands and CAMBRIDGE, Mass., Feb. 05, 2025 (GLOBE NEWSWIRE) -- Merus N.V. (Nasdaq: MRUS) (Merus, the Company, we, or our), a ...
Merus N.V.: New England Journal of Medicine Publishes: Efficacy of Zenocutuzumab in NRG1 Fusion-Positive Cancer
UTRECHT, The Netherlands and CAMBRIDGE, Mass., Feb. 05, 2025(Nasdaq: MRUS) (Merus, the Company, we, or our), a clinical-stage oncology company developing innovative, full-length multispecific antibodi ...
Orthopedics This Week5h
When Surgery Isn’t an Option, This Knee Tumor May Still Be Treated
Your patient presents with pain, swelling and impaired knee function. One rare diagnosis is non-malignant tenosynovial giant ...
Frontiers29d
Aspartate aminotransferase to platelet ratio correlates with poor prognosis and metabolic alterations in Dabie bandavirus infection
The aspartate aminotransferase to platelet ratio index (APRI) is a biomarker of liver injury and inflammation. This study aimed to examine the correlation between APRI and SFTS prognosis using ...