Key mediators underlying these effects are shown. The fate of activated stellate cells during resolution of liver injury is uncertain, but may include reversion to a quiescent phenotype and/or ...

Stellate cell "activation" is a key event in liver injury, and refers to the ... Cells with features of both quiescent and activated states are often called "transitional cells." ...

az.vub.ac.be Accumulating evidence suggests that stellate cells are involved in the regulation of the liver microcirculation and portal hypertension. Activated hepatic stellate cells have the ...

jpi{at}soton.ac.uk BACKGROUND Activated hepatic stellate cells (HSC) are central to the pathogenesis of liver fibrosis, both as a source of fibrillar collagens that characterise fibrosis and matrix ...

Activated hepatic stellate cells adopt a myofibroblast phenotype and increase production and deposition of ECM components leading to liver fibrosis which can eventually progress to liver cirrhosis. Up ...

Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, ...

In 2009 a team of biophysicists led by Anthony A. Hyman of the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden, Germany, were studying specklelike structures called P ...

A recent study from Tata Institute of Fundamental Research, Mumbai, India has revealed new details about how our cells clean up and recycle waste. This process, known as autophagy, is like a self ...

Separately, drinking damages liver cells trying to metabolize alcohol and can lead to additional fat buildup. The inflammation and scarring caused by excess fat may eventually lead to cirrhosis ...