Novel test systems for cardiac liabilities, including tests on human stem cell-derived cardiomyocytes, are continuously being developed and deliver valuable information beyond pure hERG channel ...

We use conventional and fluorescence-based electrophysiological techniques to investigate the mechanisms underlying drug inhibition and activation of hERG channels. Cardiomyocytes derived from human ...

A major focus of our research is on hERG channels, which are critical to normal cardiac ... CRISPR-Cas9 gene-editing, iPSC-derived cardiomyocytes, zebrafish hearts, heterologous expression systems ...