Specific ubiquitin–UBD interactions are crucial for the regulation of multiple cellular functions, including protein stability, receptor trafficking, DNA damage responses and inflammatory pathways.

Ubiquitylation is a reversible post-translational modification involved in a myriad of cellular functions. A superfamily of approximately 100 ubiquitin-specific proteases, called deubiquitylating ...

Ubiquitin ligases regulate many processes in ... Dimerization is, therefore, an important regulatory mechanism." "If HACE1 no longer functions correctly in the cell or is missing altogether ...

A disrupted protein degradation process in heart muscle cells can lead to a range of severe heart diseases. In the case of ...

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart -- an important process for maintaining heart health.

A new study has identified an enzyme that plays an important role in breaking down unneeded or damaged proteins in the heart – an important process for maintaining heart health.

An enzyme called Ubiquitin-specific peptidase 5 is a key factor in protein quality in heart muscle cellsA disrupted protein ...

E1 enzymes facilitate conjugation of ubiquitin and ubiquitin-like proteins through adenylation ... that uncovered at least three critical E2 residues that were important for function in vivo and for ...