Nature1mon
Interleukin-3 protects Bcr-Abl-transformed hematopoietic progenitor cells from apoptosis induced by Bcr-Abl tyrosine kinase inhibitors
The activity of a recombinant insulin receptor tyrosine kinase was measured using Raytide (Calbiochem, La Jolla, CA, USA) as substrate. The conditions for the in vitro kinase assays were as ...
News Medical on MSN1d
Adrenomedullin hormone as key driver of insulin resistance in obesity-linked type 2 diabetes
Researchers investigate the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
ophthalmologytimes16d
Tyrosine kinase inhibitor: An alternative treatment for non–small-cell lung cancer metastasis to the choroid
Investigators conducted a retrospective review that spanned 10 years with the goals of describing the clinical characteristics of choroidal metastasis in this patient population and report treatment ...
High levels of adrenomedullin found to promote obesity-associated insulin resistance
Adrenomedullin (ADM) inhibits endothelial insulin signaling, contributing to obesity-associated insulin resistance, according ...
Nature10d
The anaplastic lymphoma kinase in the pathogenesis of cancer
Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first identified in a chromosomal translocation associated with some anaplastic large cell lymphomas (ALCL), a subset of T-cell non ...
Too Old to Operate9d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
Monthly Prescribing Reference1mon
December 2024 Recap: Drug Pipeline Updates
NDA accepted for review Zynquista (Lexicon Pharmaceuticals) Dual sodium-glucose co-transporter types 1 and 2 inhibitor As an adjunct to insulin ... penetant Bruton tyrosine kinase inhibitor ...