Too Old to Operate5d
Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax.
Disparate pathogenic mechanisms complicate precision-medicine efforts to treat diffuse large B-cell lymphoma (DLBCL), the most common lymphoma diagnosis. Though potentially curable with frontline ...
BioWorld12d
PTP1B allosteric inhibitor enhances glucose uptake in insulin resistance models
Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) acts as a negative regulator of the insulin signaling pathway by dephosphorylating both the insulin receptor (IR) and the insulin receptor ...
Monthly Prescribing Reference25d
December 2024 Recap: Drug Pipeline Updates
NDA accepted for review Zynquista (Lexicon Pharmaceuticals) Dual sodium-glucose co-transporter types 1 and 2 inhibitor As an adjunct to insulin ... penetant Bruton tyrosine kinase inhibitor ...
Nature11mon
Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α
Figure 3: Lower glucose and insulin concentrations in Pik3r1 −/− mice. Figure 4: Biochemical analysis of Pi3k expression and activity in insulin-responsive tissues. For glucose tolerance tests ...