How does DNA recombination work? It occurs frequently in many different cell types, and it has important implications for genomic integrity, evolution, and human disease. In the alternate pathway ...

Radiation therapy (also called radiotherapy) is a critically important type of cancer ... Homologous recombination promotes non-immunogenic mitotic cell death upon DNA damage, Nature Cell Biology ...

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction.

Gene therapy has shown potential in treating various genetic disorders, such as sickle cell anemia, cystic fibrosis, and certain types of cancer. Recombinant DNA technology has revolutionized vaccine ...

DNA (deoxyribonucleic acid), the molecular "blueprint" carrying the genetic instructions that influence the growth, ...

All human genetic diversity can be traced to recombination and de novo mutations, DNA sequences present in the child but not in the parents. The map shows that mutations are elevated near regions ...

Recombinant DNA is one of the first stories in modern biotechnology history. The National Museum of American History contains collections which trace this foundational technique of genetic engineering ...

In the context of the NIH Guidelines for Research Involving Recombinant DNA Molecules, recombinant DNA molecules are defined as either: molecules that are constructed outside living cells by joining ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

DNA damage is a natural occurrence in ... but they're only used in homologous recombination deficient cancer types—for example, the BRCA1 and BRCA2 mutations," said Qingshu Meng, Ph.D., a ...

The most common type of mistake is a point substitution ... meiosis in unequal crossing over events, slippage during DNA recombination or due to the activities of transposable events.