"Each gene was like a single word. However, there was a piece of critical information lacking: transcription initiation sites for individual genes." Transcription initiation sites are locations in ...

If DNA is a book, then how is it read? Learn more about the DNA transcription process, where DNA is converted to RNA, a more portable set of instructions for the cell. The process of transcription ...

Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been ...

In the absence of sigma, transcription initiation forms harmful R-loops unless RapA can intervene first, prying open the RNAP clamp. "RNAP is like a big claw that closes around DNA," Darst says.

Our multi-disciplinary research program aims to understand the molecular architecture and recognition features of the early events in transcription initiation, and to use these insights to develop ...