Infection with hepatitis D viruses causes severe inflammation of the liver. An MHH team has now identified a marker on natural killer cells that is influenced by the anti-inflammatory effectiveness of ...

The company identified PVRIG and TIGIT as immune checkpoints in the DNAM axis, an important signaling pathway in T- and NK-cell function, which led to the discovery and development of novel ...

scientific understanding of the anti-TIGIT pathway and new avenues in cancer research.” Roche has another half-dozen phase 3 trials on the go with tiragolumab in other NSCLC settings ...

Of the results, iTeos president and CEO Michel Detheux said: “While the initial signal for ... immunosuppressive pathways. These include its Phase III trial of its TIGIT antibody belrestotug ...

At the time, Barron said that combinations of a PD-1 with TIGIT, CD96 and PVRIG inhibitors – the latter three all acting around the CD226 pathway – could become transformative medicines for ...