Hosted on MSN1mon
Study discovers Foxo3 protein helps eliminate 'unfit' cells to ensure healthy body construction
a membrane protein, enables neighboring cells to sense and respond to cells with abnormal Shh activity, and that the removal of unfit cells occurs via a specific pathway—the Smad/Foxo3/reactive ...
EurekAlert!3y
pVHL and SMAD occur complementary (IMAGE)
Stained liver tissue shows the complementary occurrence of pVHL and SMAD proteins: Where pVHL (green) is abundant, SMAD2/3 (red) is scarce, and vice versa. Cell nuclei are stained blue.
Nature1mon
Integrating Myc and TGF-β signalling in cell-cycle control
The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell ...