The core components for small RNA biogenesis and effector functions have proliferated and specialized in eukaryotic lineages, resulting in diversified pathways that control expression of ...

UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

as proposed for the spliceosome), enzymatic activity might be intrinsic to the RNA. Ongoing studies of snRNPs and snoRNPs have revealed unexpectedly elaborate biogenesis pathways. These RNAs can ...

Trypanosomes are parasites that cause sleeping sickness, Chagas disease, and various animal diseases. Diagnosis and treatment remain complex and no effective vaccine has been developed. A better ...

In another study in collaboration with the Narry Kim lab (Seoul National University), we demonstrated that 5’-phosphorylated end recognition by Dicer is important for precise and effective biogenesis ...

Proteins that trigger cell senescence occupy much of the literature on aging, but a small RNA moves into the limelight ... noted that the authors used many different methods to validate the pathway ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA ... and secondary metabolic pathways, particularly ...

Importantly, ManS was produced by a noncanonical biogenesis mechanism: The ribonuclease RNase III, which usually cuts double-stranded RNA ... and secondary metabolic pathways, particularly ...