An artist's representation of a free-energy landscape and two possible paths a protein might follow (left) to fold correctly and a third path (right) that leads to a misfolded state. Disclaimer ...

While part of the barrier to the folding of small proteins thus appears to be enthalpic, α-lytic protease, a protein with a huge free energy barrier to folding, actually has a negative activation ...

The energy landscape theory ... funneled landscape that otherwise guides the folding, called local frustration, are essential ...

as they direct folding pathways by impacting the energy and stability of the new peptide chains. By experimentally capturing and imaging snapshots of protein synthesis of nascent chains on their ...

This kind of tight folding and packing minimizes the overall free energy of the protein. An average protein has about 300 amino acid residues. If we consider that there are twenty different amino ...

Already a Honolulu Star-Advertiser subscriber? Log in now to continue reading. Moreover, protein folding doesn’t happen in isolation. Inside cells there are specialized molecules called ...

“Eliminating unlikely structures that have, for instance, hydrophobic residues exposed to solvent, the program intelligently samples the total protein-folding landscape, testing perhaps a million or ...

ATP-driven conformational cycle of Hsp90 These fundamental questions will be answered by combining structural tools (x-ray crystallography, NMR, FRET, small angle x-ray scattering) with the tools of ...

and it incorporates key improvements inspired by the representation learning modules from the AlphaFold2 architecture of computer-based protein folding. These modules allow the ProteinReDiff ...

The process by which a protein attains its functional structure, known as protein folding, is a complex and dynamic phenomenon. Despite decades of research, predicting a protein’s structure from ...

As a postdoc, Treuille founded the team that built the protein folding game Foldit, the first open online game that lets untrained amateurs speed up biochemical research by solving fun visual puzzles.