Heat-shock protein 90 (Hsp90) inhibitor downregulates c-Myc expression and upregulates the expression of tumor repressor proteins such as p53 and pRB, inhibiting the G1/S transition and causing G2 ...
Cleavage of Caspase 3, PARP1 and HSP90, as well as increased Annexin V ... Moreover, this combination is active against P53-negative and FLT3-ITD-positive cell lines. Enhanced activation of ...
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