What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers of two to perhaps 48 residues, are not ...

Reference: Pistofidis A, Ma P, Li Z, Munro K, Houk KN, Schmeing TM. Structures and mechanism of condensation in nonribosomal peptide synthesis. Nature. 2024. doi: 10.1038/s41586-024-08417-6 This ...

The molecular machines that Pistofidis and Schmeing studied are called nonribosomal peptide synthetases, or NRPSs. They build some of the most important compounds in current health care and ...

Organisms use enzymes to produce nonribosomal peptides, and ribosomes to produce proteins via reactions that differ in details from dehydration synthesis. Some peptides, like alpha-amanitin, are ...

Nonribosomal peptides (NRPs) are a diverse class of natural ... This research not only clarifies the synthesis process but also opens avenues for re-engineering NRPSs to create new pharmaceutical ...