In monogenic hypertensive disorders, single gene mutations lead to either a primary increase in the rate of sodium and chloride reabsorption in the distal nephron or enhancement of the effects of ...

One example of a Y-linked disorder is ... In recent years, a number of diseases initially characterized as monogenic have been shown to be caused or modified by an additional gene or genes.

For example, some complex human diseases involve multiple symptoms that may fail to transmit in a single package; without the presence of a consistent set of symptoms among affected individuals ...

During the past decade, Parkinson disease (PD) has evolved from a textbook example of a mostly nonhereditary disease to a complex disorder with ... of different forms of monogenic PD has revealed ...