(A) Electron micrograph of a human cell section showing three mitochondria ... ubiquinone in green labeled with a Q; cytochrome c reductase in light blue; cytochrome c in dark blue labeled ...

Cytochrome C oxidase stains revealed an absence ... tissue showed an increase in the number and size of the mitochondria, especially in subsarcolemmal locations—many showing abnormal crista structure ...

This was associated with translocation of cytochrome-c from the mitochondria to the cytosol, resulting in activation of the caspase cascade via caspase-9. Key executioner enzymes were caspases-3 and ...