A study on COVID-19 patients highlighted the role of MASP-2 in the lectin pathway of complement activation. The researchers developed a sensitive assay to measure MASP-2 levels and found that its ...

Omeros’ first-in-class monoclonal antibody inhibiting the lectin pathway of complement, in the treatment of hematopoietic stem cell transplant-associated thrombotic microangiopathy (TA-TMA), a ...

During his doctoral research, Umakhanth investigated the protein-protein interactions leading to the lectin pathway of complement activation, an important component of innate immune system. His ...

Narsoplimab, also known as OMS721, is a monoclonal antibody targeting MASP-2, a key player in the lectin pathway of the complement system. The drug has received breakthrough therapy and orphan ...

Endothelial damage, which activates the lectin pathway of complement, plays a central role in the development of TA-TMA. The condition occurs in both autologous and allogeneic transplants but is ...