Investigational models like the histamine-induced skin wheal-and-flare ... the most accurate indicator of the effectiveness of an H 1-receptor antagonist in clinical practice.

The type of allergic reaction depends on which receptors histamine binds to when it is released. For example, when histamine ...

This observation led Swedish investigators to propose, in 1948, that there are two types of receptors sensitive to histamine, and close to two decades later British researchers gave the name H1 to ...

Vogt produce histamine synthetically by removing the ... 1972—James Black discovers the H2 receptor and characterizes its antagonist, burimamide. 1999—Researchers at a subsidiary of Johnson ...

Histamine was identified as a pro-porphyrinogenic factor in hepatocytes. Both H1- and H2-receptor blockade were shown to decrease PP-IX levels. CCZ treatment reduced hepatic mast cell infiltration ...

Abstract and Introduction Predicting and Establishing the Clinical Efficacy of a Histamine H Application of the Model Paradigm Conclusions References In vitro findings may correlate with the ...