Hematopoietic stem cell gene therapy (HSC-GT) represents a cutting-edge treatment strategy for multiple genetic disorders. By ...

Bone-marrow-derived stromal cells are the functional components of the haematopoietic stem cell (HSC) niche that support HSC homeostasis and they have anti-proliferative features that are in ...

The findings are published in the journal Cell Stem Cell. "We've shown that this decline in HSC function is not inevitable and appears to be reversible," said study senior and co-corresponding ...

The pre-HSCs (HSC progenitors) are stimulated by SCF derived from endothelium in the dorsal aorta, but not by TPO. After migrating to the fetal liver, pre-HSCs receive both SCF and TPO signals ...

Featured data showcase the transformative potential of HSC gene therapy to enable cross-correction and restore enzymatic ...

[HSC] are clinically proved to be useful, so it really drives further research to better understand their regulation,” remarked Rong Lu, a stem cell biologist at the University of Southern California.

report attempts to define a common stem-cell gene profile by comparing hematopoietic and neural stem-cells (Proc Natl Acad Sci USA 2001, 98:7934-7939). They isolated hematopoietic stem cells (HSC) ...

We have developed a protocol to direct the differentiation of human induced pluripotent stem cells (iPSC) to HSCs. The final HSC–like population was enriched in PDGFRß positive cells and expressed key ...

We discovered that interferon gamma (IFNγ) promotes hematopoietic stem cell (HSC) division and myeloid differentiation in a mouse model of Mycobacterium avium infection (Nature 2010). Furthermore, ...