DNA transcription is the vital first step needed for switching on our genes. For a gene to be switched on, it must be acted ...

Some of these “enhancers” regulatory sequences function similarly to the dimmer switches that control the lighting in the living room. In fact, when and where a specific gene is needed ...

Enhancer Biology lab studies gene regulation and genome architecture controlled by transcription factors using genome-wide functional genomics methods. Our aim is to understand enhancer malfunction ...

However, these same technologies could also take reprogenetics beyond disease prevention into the realm of genetic enhancement, where such matters as a child's eye or skin color, height ...

This work sheds light on how these elements contribute to cell-specific gene expression and how mutations within them may influence health and disease. CREs, including enhancers and promoters ...

We will eventually move from embryo selection and disease prevention to gene alteration and trait enhancement.