foot ulcers and even gangrene, necessitating leg-saving surgery or major amputation. This end-stage of the disease is called chronic limb-threatening ischemia. The survival of people with this ...

9 With regard to the etiology of foot ulceration, traditionally it is stated that 45–60% of ulcers are purely neuropathic, about 10% are purely ischemic and 25–45% are of mixed, neuroischemic ...