Cyclin-dependent kinases (CDKs) trigger the transition from G1 to S phase and from G2 to M phase by phosphorylating distinct sets of substrates. (B) CDK1 and CDK2 bind to multiple cyclins (cyclin ...

Substantial evidence indicates that this is mediated by the rapid activation of cyclin B–Cdk1, which is the core component of M-phase-promoting factor (MPF). This kinase was initially identified ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz ...

This normally also degrades the Cdk1 activator cyclin B. If the researchers next prevented cyclin B degradation or expressed non-degradable cyclin B and then washed out the Cdk1 inhibitors, the cells ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct order. Two studies by researchers at the University of Konstanz investigated ...