Cyclin-dependent kinases (CDKs) trigger the transition from G1 to S phase and from G2 to M phase by phosphorylating distinct sets of substrates. (B) CDK1 and CDK2 bind to multiple cyclins (cyclin ...

A "pocket" on the protein cyclin B is responsible for ensuring that the steps of cell division take place in the correct ...

Substantial evidence indicates that this is mediated by the rapid activation of cyclin B–Cdk1, which is the core component of M-phase-promoting factor (MPF). This kinase was initially identified ...

Cell division is essential for the survival of all living organisms, from the simplest yeast to complex human beings.