Costimulatory molecules, the signals of which act in tandem with those from the T cell receptor (TCR) to activate cellular immunity, can help fuel antitumor activity. The promise of costimulatory ...

3 Despite increased costimulatory molecule and cytokine expression, S28690-treated CLL cells did not cause strong proliferation of T cells in MLRs. Concomitant treatment with phorbol esters caused ...

The therapies were targeted at costimulatory molecules, B and T cells, innate immune mechanisms and mesenchymal stem cells. Results from these studies bring new insights for real effective ...

Rondo Therapeutics, a privately held biopharmaceutical immuno-oncology company pioneering the development of next-generation T cell-engaging bispecific antibodies for the treatment of solid tumors, ...