PCNA is a homotrimer that forms a ring-shaped structure that slides along the DNA following the DNA polymerase, and it also remains bound to the lagging-strand chromatin after replication has been ...

Chromatin immunoprecipitation (ChIP ... Each sample was deposited on one quadrant of the slide at a target bead density of 60,000–70,000 beads per panel. We generated two slides and processed ...

Varshavsky studied chromatin structure and wanted to develop new methods ... In the 2000s, Young’s team used DNA microarrays, which are glass slides coated with short DNA sequences, to detect genes ...