When genes are coiled and compacted into chromatin, they're no longer accessible to transcription factors. So how does the cell know where to uncoil in a process called chromatin remodeling?

First author Jason Rawlings, then at St. Jude Children’s Research Hospital, found that T cells are maintained in a quiescent state by a nonhistone protein complex involved in chromatin compaction. The ...

As chromosomes prepare to separate, the chromatin compacts. Chromosome compaction during mitosis requires the action of condensin proteins and post-translational modifications of histone proteins. In ...

However, the DNA is contained within the nucleus, which is only around 6 μm in diameter, due to compaction by packaging it as chromatin. Chromatin consists of nucleosomes, the basic structural unit of ...