The two centrioles together with their associated pericentriolar material constitute the ‘centrosome’. In motile animal cells, such as fibroblasts or macrophages, the centrosome typically ...

The lack of centrioles could therefore prevent cytokinesis in all acentrosomal cell systems examined. Figure 1: Positioning of centrosomes and spindle pole bodies during exit from cytokinesis.

The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses.

The goal of my research is to understand the biogenesis of centrioles/centrosomes and primary cilia, and how defects in these processes affect mammalian cell physiology and evoke stress responses.