During the S (DNA-replication) phase of the cell cycle, each centriole cylinder duplicates through the budding of a new cylinder, which grows orthogonally to the old one. During the remainder of S ...

During the next cell cycle, the actual initiation of centriole duplication occurs only when cytoplasmic conditions become permissive during S phase. Figure 2: Mechanisms of centriole reduplication ...

Moreover, only MTOC-competent centrioles are allowed to duplicate in S phase, and are capable of bringing their newborn daughters to spindle poles in mitosis for segregation. We have thus uncovered a ...