From live-action to classic friendships, top productions like Disney and Nickelodeon have created female iconic cartoon duos with polarising personalities playing off one another with comedic timing.

Iconic duos abound in popular culture. Sometimes, those duos aren’t even flesh and blood. Beloved pairs also exist in the world of animation. There, they don’t even necessarily need to be human.

This list contains only the best cartoon duos, actor duos from movies or TV shows, and celebrity and music duos. Renowned film critic Cideshow explained the significance a duo could have.