Another promising avenue of research involves the development of novel inhibitors targeting the calcineurin-NFAT signaling pathway, particularly in the context of cancer. For instance, a new non ...

The characteristics of a second main signaling pathway that used the phosphoinositide-derived second messengers diacylglycerol and inositol trisphosphate were just beginning to be described.

It is assumed that calcium compartmentalization and distinct patterns of calcium concentration waveforms trigger specific signal-transduction pathways that are otherwise insensitive to the moment ...

We have focused on identifying how molecular lesions in protein synthesis initiation signaling pathways and the regulation of the phosphatase, calcineurin, play a role in the manifestation of cellular ...