In the p53 pathway, signals such as DNA damage induce the ARF (also known as p14 in humans and p19 in mice) product of the CDKN2A locus. ARF increases p53 levels by sequestering MDM2, which ...
The RaDAR (RanGDP/AR) pathway is acquired by the most common familial melanoma associated CDKN2A mutation ... the existence of an Ankyrin repeats signaling and its role in infection and cancer.
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