Talavera de la Reina is a city and municipality of Spain, part of the autonomous community of Castile–La Mancha. Its population of 83,3…Talavera de la Reina is a city and municipality of Spain, part of the autonomous community of Castile–La Mancha. Its population of 83,303 makes it the second most populated municipality of the province of Toledo and the fourth largest in the region.